While no specific supplements have been definitively proven to be harmful for endometriosis, women with endometriosis should be cautious with certain supplements that could potentially exacerbate their condition or interact negatively with their treatment plan.

Bloating and abdominal issues

Be mindful of supplements containing sugar alcohols (i.e. sorbitol and xylitol), certain fibers (i.e. inulin and chicory root), probiotics, artificial sweeteners (i.e. aspartame and sucralose), lactose, high sodium levels, and added yeast. These ingredients can cause bloating and other abdominal issues¹. Additionally, excess intake of magnesium and iron can lead to constipation, diarrhoea, nausea, and abdominal pain².

Herbs with Estrogenic Effects

Be cautious of herbs that can affect hormone levels. Herbs like red clover, black cohosh, and licorice root have estrogenic properties³, which may not be suitable for women with endometriosis. While some studies suggest potential benefits³, others indicate no significant effects. Herbs may also contain active substances that can trigger side effects and interact with other medications. Take herbal supplements under the supervision of your healthcare provider.

Hormone Supplement DHEA

The use of DHEA (Dehydroepiandrosterone) is particularly controversial for women with endometriosis. Although DHEA might benefit conditions like adrenal insufficiency⁴ and age-related hormone decline⁴, it can raise estrogen levels, posing a risk of worsening endometriosis symptoms. Due to this potential risk, DHEA should be approached with caution.

Mislabelling and Quality Concerns

Mislabelling is a significant issue with supplements⁵, especially those purchased online. Products often lack adequate information, and labels may not provide accurate details. This can result in the use of toxic plant species due to adulteration or substitution⁵. Make sure you purchase products of high quality and based on your practitioner’s recommendations.

Women with endometriosis should always consult with a healthcare provider before starting any new supplements. A healthcare professional can provide personalized advice based on your needs.

References

1. Hasler W L. Gas and Bloating.  Gastroenterol Hepatol (N Y). 2006 Sep; 2(9): 654–662.  PMID: 28316536.
2. Moses G. The safety of commonly used vitamins and minerals.  Aust Prescr. 2021 Aug; 44(4): 119–123.  DOI: 10.18773/austprescr.2021.029
3. M IIhan, Dereli F T G & Akkol E K. Novel Drug Targets with Traditional Herbal Medicines for Overcoming Endometriosis.  Curr Drug Deliv. 2019 Jun; 16(5): 386–399. DOI: 10.2174/1567201816666181227112421.
4. Jethwani P, Rastogi A &, Shukla R.  Dehydroepiandrosterone sulfate supplementation in health and diseases. World J Meta-Anal 2023; 11(4): 102-111.  DOI: 10.13105/wjma.v11.i4.102..
5. Navarro V, Avula B, Khan I, et al. The Contents of Herbal and Dietary Supplements Implicated in Liver Injury in the United States Are Frequently Mislabeled.  Hepatol Commun. 2019 Jun; 3(6): 792–794. DOI: 10.1002/hep4.1346